• In contrast to drospirenone dydrogestrone acts rather

  2021-08-30

  

  In Malotilate to drospirenone dydrogestrone acts rather neutral at the aldosterone-, glucocorticoid- and androgen-receptor [12]. This indicates that the assessment of a ‘net-overall effect’ on the vascular system is very difficult based on the often discussed ‘partial effects’ of the progestogens.

• LB Broth, Miller Recent pharmacological and clinical studies

  2021-08-30

  

  Recent pharmacological and clinical studies suggested that estetrol (E4) should also be considered as an interesting candidate for MHT (Abot et al., 2014; Mawet et al., 2015). E4 is naturally produced from E2 and estriol (E3) via 15α- and 16α-hydroxylase by the human fetal liver during pregnancy and

• br Conflicts of interest br Acknowledgements This work

  2021-08-30

  

  Conflicts of interest Acknowledgements This work was supported, in part or in whole, by the grants from the National Natural Science Foundation of China (11802056, 11772088), the China Postdoctoral Science Foundation (2018M640904), and the Fundamental Research Funds for the Central Universitie

• br Materials and methods br Results

  2021-08-30

  

  Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te

• The question remains however as to

  2021-08-30

  

  The question remains, however as to the downstream signaling by Epacs that contributes to persistent sensitization of sensory neurons. Activation of the Ras family of GTPases by Epac1 (RapGEF3) or Epac2 (RapGEF4) (Bos, 2003, de Rooij et al., 1998) is linked to a number of downstream signaling effect

• br Conclusions We can conclude that Arg is important

  2021-08-30

  

  Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o

• The Acat gene was identified by functional complementation o

  2021-08-30

  

  The Acat1 gene was identified by functional complementation of a Chinese hamster ovary cell mutant lacking ACAT activity [12]. Unlike most other genes, human Acat1 is located in two different chromosomes, PYR-41 mg 1 and 7, with each site containing a distinct promoter: chromosome 1 contains exons

• br Materials and methods br Results br

  2021-08-30

  

  Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial ST 2825 where it physically promotes vasodilation [32]. Conversely, evidence also indicates tha

• DDR is one of two

  2021-08-30

  

  DDR1 is one of two, non-integrin tyrosine kinase receptors activated by collagen. Although DDR1 has five isoforms (1a, 1b, 1c, 1d, 1e) generated by alternative splicing, only DDR1a and 1b have active kinase domains, whereas DDR2, encoded by a distinct gene, has one isoform (Vogel et al., 2006). Coll

• szl br Material and methods br Results

  2021-08-30

  

  Material and methods Results Discussion Isolated szl have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, they make it

• From these and other studies it is clear

  2021-08-30

  

  From these and other studies, it is clear that acriflavine is an interesting Benztropine mesylate with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for ca

• The development of novel approaches

  2021-08-30

  

  The development of novel approaches to study GPCR-mediated transactivation in live OG-L002 is important, and this study describes a unique BRET-based quantification of Grb2 recruitment to the EGFR as a direct readout of GPCR-mediated transactivation. We have previously used the recruitment of Grb2

• br Regulation of p via the ubiquitin proteasome pathway

  2021-08-30

  

  Regulation of p53 via the ubiquitin-proteasome pathway Studies into regulation of p53 via PTM processes that involve phosphorylation, acetylation, ubiquitination, SUMOylation, neddylation, and methylation are being increasingly reported [23], [24]. Phosphorylation and acetylation of p53 stimulate

• Finally unilateral microinjection of CP Astressin

  2021-08-28

  

  Finally, unilateral microinjection of CP-376395, Astressin 2B, CP-376395 + CRF or ASTR 2B + CRF into the BLA (Fig. 3A) or CeA (Fig. 3B) did not significantly alter spontaneous motor activity in the open field test (F4,24 = 0.148, P > 0.05; F4,29 = 0.290, P > 0.05 in the BLA and CeA, respectively, AN

• br Model parameterization br Results and discussion br Concl

  2021-08-28

  

  Model parameterization Results and discussion Conclusion Following an approach previously proposed for SAFT-VR model, we have used PR-CPA EoS without explicitly accounting for the reactions for the modeling of CO2 and H2S-water-alkanolamine solutions. The reactions between acid gases and wa

15619 records 586/1042 page Previous Next First page 上5页 586587588589590 下5页 Last page