• br Hypothesis The hypothesis is that AhR in skin

  2023-07-27

  

  Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un

• In a recent series of studies from

  2023-07-27

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat AGK7 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contract

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2023-07-27

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the DZNep and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors (

• TAPI-1 The biological characteristics of cancer invasion

  2023-07-27

  

  The biological characteristics of cancer invasion and metastasis are mainly attributed to the poor prognosis in cancer. It has been reported that overexpression of Ack1 promoted the migratory and invasive properties of breast cancer TAPI-1 by sustaining expression of epidermal growth factor. In cont

• The acetylcholinesterase AChE inhibitor tacrine THA exerts n

  2023-07-27

  

  The acetylcholinesterase (AChE) inhibitor, tacrine (THA), exerts neuroprotective effects in time- and does-dependent manners against glutamate neurotoxicity (Takada-Takatori et al., 2006a, 2006b) and amyloid-β protein toxicity in PC12, a pheochromocytoma line (Wang et al., 2002; Xiao et al., 2000).

• nebivolol hcl br Experimental procedure br Introduction

  2023-07-26

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Consistent with the observation that mutations in the

  2023-07-26

  

  Consistent with the observation that mutations in the redox-partner binding site of P450c17 that reverse charge from basic to acidic (R347H, R358Q) cause 17,20-lyase deficiency (Geller et al, 1997, Geller et al, 1999), at least one POR mutation that changes a residue in the FMN domain from neutral t

• br Increased blood ATX and LPA in liver fibrosis

  2023-07-26

  

  Increased blood ATX and LPA in liver fibrosis Although previous in vitro findings have suggested a link between LPA and liver fibrosis in vivo, whether LPA plays a primary role in the pathogenesis of liver fibrosis has remained uncertain. No phenotypic changes in livers of LPA receptor-deficient

• br The complementary role of chaperone mediated

  2023-07-26

  

  The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa

• br Conclusions and future direction

  2023-07-26

  

  Conclusions and future direction ER(−)/PgR(+) breast cancers have a distinct clinical course, response to treatment, and molecular features when compared to other breast cancer types, however some of them are actually technical artifacts or consequences of too high definitions of positivity. Acco

• The compounds containing beryllium act as strong Lewis acids

  2023-07-26

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be mp 1 []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentate Be-base

• br Introducing toll like receptors TLRs are the most

  2023-07-26

  

  Introducing toll like receptors TLRs are the most important receptors which are expressed on the cytoplasmic and internal vesicles membrane. They have a similar structure including a leucine-rich repeats (LRRs) domain which is out of LY3009120 membrane, a hydrophobic transmembrane and a toll/int

• br Author contributions br Conflicts of interest The authors

  2023-07-26

  

  Author contributions Conflicts of interest The authors declare no competing financial interests. Acknowledgement This work was supported by grants from the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich/Transregio 166–Project C1 and grant CA 1014/1-1 to D.C.) and the IZKF Würzbur

• Thymoquinone TQ is the major active compound derived from

  2023-07-26

  

  Thymoquinone (TQ) is the major active 4-DAMP derived from Nigella sativa (Woo et al., 2012). Recent animal studies support the potential of TQ for the treatment of a variety of inflammatory disorders like inflammatory bowel disease (IBD), RA, and osteoarthritis (OA) (Salem, 2005, Badr et al., 2011).

• In addition to connecting high ARG levels with DNMT

  2023-07-26

  

  In addition to connecting high ARG1 levels with DNMT3A/TET2 mutations in MDS/CMML patient biopsies, we also wanted to address the cell type demonstrating elevated ARG1. Following our mouse work, we hypothesized that overexpression of this protein would be found in myelomonocytic nordihydroguaiaretic

15968 records 311/1065 page Previous Next First page 上5页 311312313314315 下5页 Last page