• We demonstrate a role for low oxygen to regulate ATX

  2024-01-17

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 Bilirubin receptor and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX m

• Autophagy is a highly conservative intracellular bulk

  2024-01-17

  

  Autophagy is a highly conservative intracellular bulk degradation process including three major forms namely microautophagy, chaperone-mediated autophagy and macroautophagy. A large number of evidence has depicted a pivotal role for autophagy in the maintenance of cardiac geometry and contractile fu

• ap4 Endoplasmic reticulum ER stress resulting from accumulat

  2024-01-17

  

  Endoplasmic reticulum (ER) stress resulting from accumulation of misfolded proteins in ER lumen stimulates a chain of adaptive responses termed as the unfolded protein response (UPR). Glucose related protein (GRP78/BiP), key ER chaperone essential for the activation of the ER-transmembrane signaling

• br Acknowledgement This work was funded by

  2024-01-17

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

• Congruously our findings of voltage

  2024-01-17

  

  Congruously, our findings of voltage-electrode-clamping assays indicate that hipN851K mutation mediates partial loss of Na+/K+-ATPase pump currents, also confirming our thesis that hipN851K mutation acts as a hypomorph. As demonstrated here by our external electrical stimulation studies and ECG reco

• br The role of apelin in respiratory

  2024-01-17

  

  The role of apelin in respiratory diseases At present, several scientific studies have suggested that the apelin/APJ system may play an important role in the development of pulmonary diseases (Table 4). For example, in an experiment on rats suffering from acute lung injury, apelin-13 decreases th

• Therefore VEGF and its receptors are expressed in different

  2024-01-17

  

  Therefore, VEGF and its receptors are expressed in different organs, including the kidneys, the liver and the Mouse iPSC Chemical Reprogramming Cocktails Kit plus [55]. In the human placenta, VEGF is mainly synthesized by cytotrophoblast and Hofbauer cells early in the first trimester, whereas Flk-1

• With wide spread use of corticosteroids to combat

  2024-01-17

  

  With wide-spread use of corticosteroids to combat inflammation and allergies, even children are susceptible to corticosteroid-induced muscle wasting. Although non-steroidal SGRMs that spare muscle and bone, but have significant anti-inflammatory effects, have been preclinically developed and tested,

• Consistent with the in vitro results

  2024-01-17

  

  Consistent with the in vitro results, memantine ameliorated Aβ-induced cytotoxicity in rat primary cortical cultures. Studies reported that memantine protected neurons against the damage caused by aggregated Aβ40 or Aβ42 oligomers in vivo[26], [27]. These results suggest that, in addition to its neu

• Besides the described changes in

  2024-01-17

  

  Besides the described changes in protein expression and thus in current amplitudes, W146 receptor of PORCN also leads to accelerated decay kinetics of evoked and spontaneous AMPAR currents. These changes in channel kinetics are most likely a secondary effect due to the selective depletion of γ-8 but

• br Introduction br Rac dependent ROS

  2024-01-16

  

  Introduction Rac1-dependent ROS and methosulfate sale regulation in neuronal functions NOX-mediated ROS have an important role as physiological messengers. One remarkable example regarding such a function is during axonal formation. In this line, increased p40phox/NOX2 levels and co-localizati

• br Experimental procedure br Introduction

  2024-01-16

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Based on currently available knowledge autophagy supports ad

  2024-01-16

  

  Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle oxytocin receptor of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD). In

• Acknowledgments br Introduction Prostate cancer is the first

  2024-01-16

  

  Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi

• The tumor suppressor function of LOX in normal prostate epit

  2024-01-16

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

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